摘要 / Abstract
摘要
神经退行性疾病是一类以神经细胞逐渐退化和功能受损为特征的疾病，目前尚无根治性治疗方法。免疫治疗作为一种新兴的治疗策略，已经引起了广泛关注。本综述总结了当前针对神经退行性疾病的免疫治疗策略，包括免疫调节、细胞免疫治疗和抗体治疗等方面的最新研究进展。其中，免疫调节通过调节免疫系统平衡，减少炎症反应和神经细胞损伤，显示出潜在的治疗效果。细胞免疫治疗则通过干细胞移植和免疫细胞治疗等手段，试图修复受损的神经组织，取得了一些积极的临床效果。此外，抗体治疗作为一种精准靶向治疗手段，也展现出了显著的潜力。综合而言，免疫治疗作为一种新颖的治疗策略，在神经退行性疾病的治疗中具有重要的临床应用前景，但仍需进一步深入研究和临床验证。
关键词
免疫治疗；阿尔茨海默病；帕金森病；神经退行性疾病
Abstract
Neurodegenerative diseases are a class of diseases characterized by progressive degeneration and functional impairment of nerve cells, and there is currently no radical treatment. As a new therapeutic strategy, immunotherapy has attracted wide attention. This review summarizes recent advances in immunotherapy strategies for neurodegenerative diseases, including immunoregulation, cellular immunotherapy, and antibody therapy. Among them, immunomodulation shows potential therapeutic effects by regulating immune system balance, reducing inflammatory response and nerve cell damage. Cellular immunotherapy attempts to repair damaged nerve tissue by means of stem cell transplantation and immune cell therapy, and has achieved some positive clinical results. In addition, antibody therapy, as a precision targeted therapy, has also shown significant potential. In summary, immunotherapy, as a novel treatment strategy, has important clinical application prospects in the treatment of neurodegenerative diseases, but it still needs further research and clinical validation.
Key words
Immunotherapy; Alzheimer's disease; Parkinson's disease; Neurodegenerative disease
参考文献 / References
[1] 黄宗晖, 周荣斌. 神经炎症与神经退行性疾病[J]. 科技导报, 2021, 39(20): 45-55.
[2] 邹添添, 覃伟, 朱迎, 等. 肝癌免疫微环境与免疫治疗: 研究进展与发展趋势[J]. 中国普通外科杂志, 2020, 29(7): 785-797
[3]黄宗晖, 周荣斌. 神经炎症与神经退行性疾病[J]. 科技导报, 2021, 39(20): 45-55
[4] 李婉琳, 宋勋, 叶亮, 等. 阿尔茨海默病发病机制及药物治疗方法研究进展[J]. 中国临床神经科学, 2021, 29(5): 581-589,596.
[5] 曹津津, 宋琼, 邹春林. 细胞治疗帕金森病的研究进展[J]. Tianjin Medical Journal, 2022, 50(4).
[6] 张琴, 时珺, 陈俊, 等. 儿童脊髓性肌萎缩症 Ⅰ, Ⅱ 型合并肺部感染 49 例临床特征分析[J]. 南京医科大学学报 (自然科学版), 2022, 42(2): 222-226.
[7] 张元, 郭晓红, 刘国荣, 等. 亨廷顿病一家系报道及相关文献回顾分析[J]. 中风与神经疾病杂志, 2022, 39(1): 78-80.
[8] 丁婧, 赵琳琳, 曲扬, 等. 神经系统退行性疾病基因治疗的研究进展[J]. 中国免疫学杂志, 2020, 36(14): 1791.
[9] 杨建岭, 王佳, 吕群燕. 免疫干预新策略的研究进展及展望[J]. 中国科学基金, 2019, 2.